Description
The Monocyte Activation Test (MAT) can detect both endotoxin and non-endotoxin pyrogens in one test. Supported by many regulatory bodies, the robust MAT assay produces sensitive results based on the human immune reaction. The MAT systems for pyrogen testing, includes endotoxin and non-endotoxin pyrogen (NEP) detection.
Detection of a broad range of pyrogens: patient safety is ensured if the full range of pyrogens are tested. Like the Rabbit Pyrogen Test (RPT), MAT is effective for both endotoxin and non-endotoxin testing.
Extension of the range of products that can be tested: the most frequently applied methods, RPT, Bacterial Endotoxin Test (BET) or LAL, are limited in the product types they are able to test. The MAT offers more flexibility regarding its applications.
In vitro assay that mimics the human immune reaction: for a robust predictive model that reduces animal consumption.
Compliance with international regulations and guidelines: in line with ethical trends of industry and regulatory authorities to decrease the use of animal-based testing.
Standardized reactivity and high sensitivity (LOD 0.05 EU/mL). Convenience of a ready-to-use cell line reduces laborious lab work and avoids the need for a cell culture laboratory.
Qualified cells: in addition to being cited in the international validation of MAT, Mono-Mac-6 cells are qualified for the detection of all types of pyrogens by testing the expression of all surface Toll-Like Receptors (TLRs).